# Akt Inhibitor Suppliers for Research and Development

## Introduction to Akt Inhibitors

Akt inhibitors have become essential tools in biomedical research, particularly in the study of cancer cell signaling pathways. These small molecules specifically target the Akt protein kinase, a critical component of the PI3K/Akt/mTOR pathway that regulates cell survival, proliferation, and metabolism.

## Top Akt Inhibitor Suppliers for Research

Several reputable suppliers provide high-quality Akt inhibitors for research purposes:

### 1. Sigma-Aldrich (Merck)

Sigma-Aldrich offers a comprehensive range of Akt inhibitors, including:

• MK-2206 (a highly selective allosteric Akt inhibitor)

• Perifosine (an alkylphospholipid Akt inhibitor)

• GSK690693 (a pan-Akt inhibitor)

### 2. Selleck Chemicals

Selleck Chemicals specializes in kinase inhibitors and provides:

• Ipatasertib (GDC-0068) – a selective ATP-competitive Akt inhibitor

• Capivasertib (AZD5363) – currently in clinical trials

• TAS-117 – a novel allosteric Akt inhibitor

### 3. MedChemExpress (MCE)

MCE offers a variety of Akt inhibitors with detailed characterization data:

• AT7867 – dual Akt/p70S6K inhibitor

• CCT128930 – selective Akt2 inhibitor

• SC79 – unique Akt activator (for control studies)

## Considerations When Choosing a Supplier

When selecting an Akt inhibitor supplier for your research, consider these factors:

Quality and Purity

Look for suppliers that provide comprehensive analytical data (HPLC, NMR, MS) and certificate of analysis for each batch.

Biological Activity Verification

Preferred suppliers should offer inhibition data against specific Akt isoforms (Akt1, Akt2, Akt3) and selectivity profiles against related kinases.

Technical Support

Choose suppliers with knowledgeable technical support teams who can assist with experimental design and troubleshooting.

## Emerging Trends in Akt Inhibitor Research

The field of Akt inhibitor development is rapidly evolving with several notable trends:

Isoform-Specific Inhibitors

Recent developments focus on creating inhibitors selective for individual Akt isoforms to reduce off-target effects.

Allosteric vs ATP-Competitive Inhibitors

Researchers are comparing the advantages of allosteric inhibitors (like MK-2206) versus traditional ATP-competitive inhibitors.

Combination Therapies

Many studies now investigate Akt inhibitors in combination with other targeted therapies or immunotherapies.

## Conclusion

Selecting the right Akt inhibitor supplier is crucial for successful research outcomes. By considering factors such as product quality, technical support, and the specific needs of your research project, you can identify the most suitable supplier for your Akt inhibitor requirements. The growing number of suppliers in this space ensures researchers have access to a diverse range of high-quality compounds to advance our understanding of Akt signaling in health and disease.